| 名稱 | c-Kit V559A/BaF3 |
| 型號 | CBP73286 |
| 報價 |  |
| 特點 | c-Kit V559A/BaF3,母細胞：BaF3，培養基：1640+10%FBS+2ug/ml puromycin；KIT V559A 位于 Kit 蛋白 （PMID: 15837988） 的近膜結構域（外顯子 11）內。 V559A 導致 Kit 的組成型磷酸化，并增加患者樣本和培養細胞中的 Mapk 和 Akt 活化。 |
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藥靶細胞株 > kinase激酶細胞株 > CBP73286c-Kit V559A/BaF3
- 詳細內容
CBP73286 | |
| I. Introduction | |
Cell Line Name： | c-Kit V559A/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
KIT V559A lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 15837988). V559A results in constitutive phosphorylation of Kit and increased Mapk and Akt activation in patient samples and cultured cells (PMID: 15837988, PMID: 19047099). | |
| III. Representative Data | |
1.Sanger of c-Kit V559A/BaF3
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2. Anti-proliferation assay
Figure 2. CTG Proliferation Assay of BaF3 c-KIT V559A (C2). | |
